Head of Microbiology Department, Thong Nhat General Hospital of Dong Nai Province, Bien Hoa City, Dong Nai Province; Head of Parasitology and Microbiology Department, Hong Bang International University, Ho Chi Minh City, Vietnam
Title of the talk: Determining Procalcitonin concentration and clearance time in patients with bacterial pneumonia
Abstract
Objectives: Procalcitonin (PCT) reduces the duration of antibiotic therapy in patients with infections, especially patients with sepsis. However, there have not been many studies interpreting the role of PCT in patients with pneumonia caused by multidrug-resistant bacteria (P-MDR), especially in Vietnam. Therefore, the aim of the study was to measure PCT kinetics in patients with bacterial pneumonia.
Methods: In this longitudinal study, we analyzed PCT kinetics in 121 patients with microbiological and clinical findings confirming the evidence of bacterial pneumonia from January 2023 to October 2023.
Results: There were 65 patients with pneumonia caused by multidrug-resistant bacteria and 56 patients with pneumonia caused by non-multidrug-resistant bacteria (P-nMDR). The five most common causes of bacterial pneumonia were Klebsiella pneumoniae (32.23%), Acinetobacter baumannii (26.45%), Pseudomonas aeruginosa (22.31%), Staphylococcus aureus (8.26%), and Escherichia coli (5.79%). The median PCT level in the P-MDR group was higher than in the P-nMDR group. PCT clearance time in the P-MDR group was 2.13 times shorter than in the P-nMDR group. 64.46% of patients who had not stopped using antibiotics at the time PCT was below 0.05 ng/ml.
Conclusions: The median PCT level in the P-MDR group was higher than in the P-nMDR group. PCT clearance time in the P-MDR group was shorter than in the P-nMDR group. It is essential to conduct a randomized controlled clinical trial following this study to monitor PCT kinetics in patient groups such as COPD and bacterial pneumonia in 2024.
Biography
Nguyen Si Tuan completed his PhD at the age of 38 years from Ho Chi Minh City University of Technology and Medical doctor studies at Tan Tao University, School of Medicine. He is Head department of Microbiology, Thong Nhat General Hospital of Dong Nai Province and Head department of Parasitology and Microbiology, Hong Bang International University. He has published more than 10 papers in reputed journals.
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