Dr.
Yaser Hashem
INSERM U1212 Acides nucleiques: Regulations Naturelle et Artificielle (ARNA), Institut Europeen de Chimie et Biologie, Universite de Bordeaux, Pessac 33607, France
Title of the talk: Structural snapshots of the cytosolic and mitochondrial mRNA translation machineries in trypanosomatids
Abstract
Trypanosomatids (also called Kinetoplastids) is a group of flagellated unicellular eukaryotic parasites including human pathogens, such as Trypanosoma cruzi and Leishmania spp., etiologic agents of Chagas disease and leishmaniasis. They are potentially lethal, affecting more than 20 million people worldwide. Therapeutic strategies are extremely limited and highly toxic. The finding of new molecular targets represents one venue for the development of new therapeutic strategies. In this talk, I will show several large scale structural and functional differences in cytosolic and mitochondrial mRNA translation machineries between trypanosomatids and their mammalian hosts. Such trypanosomatids-specific features represent promising molecular targets that can be used for the development of safer and more specific drugs, poised at combatting infections caused by these dangerous parasites.
Biography
Yaser Hashem completed his PhD from the University of Strasbourg (France) in 2010 and followed up with postdoctoral studies at Columbia University (NYC, USA) with Prof. Joachim Frank (Chemistry Nobel Laureate 2017 for Cryo-EM). He is a co-director of the IECB (Bordeaux France) and a Research Director and Group Leader at the National Institute for Health and Medical Research (INSERM, France). He has published more than 45 papers in high-impact journals (Nature, Cell, Mol Cell, NSMN, Nature Commun. PNAS, etc…) on the topic of structural and functional differences in translation regulation between eukaryotic pathogens and their hosts.
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